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The biggest moment when the two were together was in "Becoming Part 2" where the two enemies formed a temporary truce and alliance in stopping Angelus from opening Acathla.
Spike: Hello, cutie.
Spike takes a step toward Buffy, and she immediately decks him twice in the face. He grabs her by the shoulders to restrain her, but she brings her knee up into his gut.
Spike: Now, you hold on a second!
He gives her a good shove away from himself. She reaches into her coat and pulls out a stake. Spike jumps back and holds up his hands in surrender.
Spike: Hey! White flag here. I quit.
Buffy: Let me clear this up for you. We're mortal enemies. We don't get time-outs.
Spike: You want to go around, pet, I'll have a gay old time of it. You want to stop Angel... we're gonna have to play this a bit differently.
Buffy: What are you talking about?
Spike: I'm talking about your ex, pet. I'm talking about putting him in the bloody ground.
Buffy: This has gotta be the *lamest* trick you guys have ever thought up.
Spike: He's got your Watcher. Right now, he's probably torturing him.
Buffy: What do you want?
Spike: I told you. I want to stop Angel. I want to save the world.
Buffy: Okay. You do remember that you're a vampire, right?
Spike: We like to talk big. Vampires do. 'I'm going to destroy the world.' That's just tough guy talk. Strutting around with your friends over a pint of blood. The truth is, I like this world. You've got... dog racing, Manchester United. And you've got people. Billions of people walking around like Happy Meals with legs. It's all right here. But then someone comes along with a vision. With a real... passion for destruction. Angel could pull it off. Goodbye, Picadilly. Farewell, Leicester Bloody Square. You know what I'm saying?
Buffy: Okay, fine. You're not down with Angel. Why would you ever come to me?
Spike: I want Dru back. I want it like it was before he came back. The way she acts around him...
Buffy: You're pathetic.
He punches her in the face. She punches him right back.
Buffy: I lost a friend tonight!
Spike: I wasn't in on that raiding party.
Buffy: And I may lose more! The whole earth may be sucked into Hell, and you want my help 'cause your girlfriend's a big ho? Well, let me take this opportunity to *not* care.
Spike: I can't fight them both alone, and neither can you!
Buffy punches him hard in the jaw, making him flinch. He straightens back up and feels his jaw, checking for blood.
Buffy: I hate you.
Spike: And I'm all you've got.
The police officer begins to stir on the hood of the car.
Buffy:All right. Talk.
Spike: I'm just gonna kill this guy [The officer].
Buffy clears her throat loudly. Spike faces her.
Spike: Oh, right.
Buffy: Let's get inside.
~"Becoming 2"
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Spike gets invited into Buffy's home and the two of them, along with Joyce asking her 20 questions figure out what they're going to do.
Joyce: Have we met?
Spike: Um... you hit me with an ax one time. Remember? (makes an ax-holding gesture) Uh, 'get the hell away from my daughter.'
Joyce: Oh.
She lets out a little chuckle. Spike sighs with boredom.
Joyce: So, do you, uh, live here in town?
Buffy walks into the room with her arms crossed. They both get up.
Joyce: I-is Willow all right?
Buffy: Yeah. She's fine. (to Spike) All right, talk. What's the deal?
Spike: Simple. You let me and Dru skip town, I help you kill Angel.
Joyce: Angel? Your boyfriend?
Buffy: (to Spike) Forget about Drusilla. She doesn't walk.
Spike: There's no deal without Dru.
Buffy: She killed Kendra.
Spike: Dru bagged a Slayer? She didn't tell me! Hey, good for her! Though not from your perspective, I suppose.
Buffy: I can't believe I invited you into my house.
Joyce: So you didn't kill that girl.
Buffy: Of course not.
Joyce: Did she explode like that man out there?
Buffy: She was a Slayer, Mom.
Joyce: Like what you are.
Buffy gives her a thin smile and a nod.
Spike: Look. This deal works for me one way. Full stop. Me and Dru for Angel.
Joyce: Honey, a-are you sure you're a Vampire Slayer?
Spike: I'll take her out of the country. You'll never hear from us again, I *bloody* well hope.
Buffy: Fine. Get back to the mansion. Make sure Giles is all right.
Joyce: I-I mean, have you tried *not* being a Slayer?
Buffy: Mom! Spike sighs in exasperation of Joyce.
Buffy: (to Spike) Be ready to back me up when I make my move.
He walks around her toward the door.
Buffy: If Giles dies... (Spike stops and faces her) she dies.
Spike gives her a final stare and heads out the door.
~"Becoming 2"
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